Journal of Pathology and Translational Medicine

Won Young Park

3 Articles

Nodular Fasciitis of the Parotid Gland, Masquerading as Pleomorphic Adenoma: Chung Su Hwang, Chang Hun Lee, Ahrong Kim, Nari Shin, Won Young Park, Min Gyoung Park, Do Youn Park; Korean J Pathol. 2014;48(5):366-370. Published online October 27, 2014; DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.5.366

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It is difficult to distinguish nodular fasciitis (NF) from other neoplasm of the parotid gland, especially pleomorphic adenoma (PA) by fine needle aspiration cytology. A 39-year-old female noticed a mass in the parotid region. The aspirate material showed cohesive parts composed of the cells that had oval or spindle-shaped nuclei and relatively abundant cytoplasm and some cells with plasmacytoid features. The background substance was fibromyxoid. PA was diagnosed based on the cytologic findings. Subsequently, parotidectomy was performed and NF was diagnosed based on histologic and immunohistochemical findings. NF in the parotid region is rare and may be misdiagnosed as other benign or malignant tumors of the parotid gland. The clinical history of rapid growth and the presence of mitoses and inflammatory cells help to distinguish NF from PA. In addition, immunohistochemical stains for smooth muscle actin and CD68 are useful to confirm the diagnosis of NF.

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A case report of nodular fasciitis of the parotid gland: An entity of concern
Andrea Varazzani, Laura Tognin, Silvia Eleonora Gazzani, Luigi Corcione, Tito Poli
Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology.2024; 36(3): 422. CrossRef
A Rare Case of Parotid Nodular Fasciitis in a Six-Month-Old Female
Mazin Merdad, Linah Qasim, Mohammed Nujoom, Hani Z Marzouki, Abdulaziz Neazy
Cureus.2023;[Epub] CrossRef
A Rare Case of Nodular Fasciitis Presenting as a Parotid Tumor: Clues to Cytodiagnosis
Seetu Palo, Chitrawati Bal Gargade
Journal of Laboratory Physicians.2023;[Epub] CrossRef
Condylar Reshape in Orthognathic Surgery: Morphovolumetric and Densitometric Analysis Based on 3D Imaging and Digital Workflow
Vincenzo Abbate, Giovanni Audino, Giovanni Dell’Aversana Orabona, Marco Friscia, Paola Bonavolontà, Carmelo Lo Faro, Umberto Committeri, Carlos Navarro Cuéllar, Giorgio Iaconetta, Luigi Califano
Journal of Maxillofacial and Oral Surgery.2022; 21(2): 501. CrossRef
Nodular fasciitis of the submandibular gland
Ting Suen Wong, Richard Wei Chern Gan, Laszlo Karsai, Bun Yin Winson Wong
BMJ Case Reports.2022; 15(4): e245584. CrossRef
Nodular fasciitis in cervicofacial region: a rare case description and literature review
Vincenzo Abbate, Giovanni Dell’Aversana Orabona, Giovanni Audino, Antonio Romano, Paola Bonavolontà, Daniela Russo, Silvia Varricchio, Roberto Ferrigno, Giorgio Iaconetta, Luigi Califano
Oral Surgery.2022; 15(4): 550. CrossRef
Nodular fasciitis of the parotid gland engulfing the facial nerve: a conservative approach
Stephen Bennett, Kristian Hutson, Olakunle Ajayi, Andreas Hilger
BMJ Case Reports.2019; 12(10): e231203. CrossRef

Mediastinal Thymolipoma with Striated Myoid Cells: Report of a Peculiar Case: Young Keum Kim, Nari Shin, Won Young Park, Do Youn Park, Gi Young Huh, Chang Hun Lee; Korean J Pathol. 2013;47(6):596-598. Published online December 24, 2013; DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.6.596

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Thymoangiolipoma: A rare histologic variant of thymolipoma in a patient with myasthenia gravis
Mohammad Hossein Anbardar, Fatemeh Amirmoezi, Armin Amirian
Rare Tumors.2020; 12: 203636132097921. CrossRef
Thymic epithelial neoplasms with rhabdomyomatous component: a clinicopathological and immunohistochemical study of 7 cases
Neda Kalhor, Cesar A. Moran
Human Pathology.2019; 83: 100. CrossRef

Prognostic Relevance of the Expression of CA IX, GLUT-1, and VEGF in Ovarian Epithelial Cancers: Kyungbin Kim, Won Young Park, Jee Yeon Kim, Mee Young Sol, Dong Hun Shin, Do Youn Park, Chang Hun Lee, Jeong Hee Lee, Kyung Un Choi; Korean J Pathol. 2012;46(6):532-540. Published online December 26, 2012; DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.532

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Abstract PDF

Background

Tumor hypoxia is associated with malignant progression and treatment resistance. Hypoxia-related factors, such as carbonic anhydrase IX (CA IX), glucose transporter-1 (GLUT-1), and vascular endothelial growth factor (VEGF) permit tumor cell adaptation to hypoxia. We attempted to elucidate the correlation of these markers with variable clinicopathological factors and overall prognosis.

Methods

Immunohistochemistry for CA IX, GLUT-1, and VEGF was performed on formalin-fixed, paraffin-embedded tissues from 125 cases of ovarian epithelial cancer (OEC).

Results

CA IX expression was significantly associated with an endometrioid and mucinous histology, nuclear grade, tumor necrosis, and mitosis. GLUT-1 expression was associated with tumor necrosis and mitosis. VEGF expression was correlated only with disease recurrence. Expression of each marker was not significant in terms of overall survival in OECs; however, there was a significant correlation between poor overall survival rate and high coexpression of these markers.

Conclusions

The present study suggests that it is questionable whether CA IX, GLUT-1, or VEGF can be used alone as independent prognostic factors in OECs. Using at least two markers helps to predict patient outcomes in total OECs. Moreover, the inhibition of two target gene combinations might prove to be a novel anticancer therapy.

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Zikuan Zhang, Bo Wu, Yuan Shao, Yongquan Chen, Dongwen Wang, Lucia Magnelli
PLOS ONE.2022; 17(12): e0278556. CrossRef
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Sunjoo An, Dongho Keum
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Responses of Autonomic Nervous System and Gastrointestinal Function to Acupuncture at Abdominal Anterior Cutaneous Nerve : A Pilot Study
Seohyun Park, Hojun Kim, Dongho Keum
Journal of Korean Medicine.2019; 40(1): 99. CrossRef
Omega-3 polyunsaturated fatty acid docosahexaenoic acid and its role in exhaustive-exercise-induced changes in female rat ovulatory cycle
Abeer F. Mostafa, Shereen M. Samir, R.M. Nagib
Canadian Journal of Physiology and Pharmacology.2018; 96(4): 395. CrossRef
Clear cell carcinomas of the ovary and kidney: clarity through genomics
Jennifer X Ji, Yi Kan Wang, Dawn R Cochrane, David G Huntsman
The Journal of Pathology.2018; 244(5): 550. CrossRef
Prognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-Analysis
Simon J. A. van Kuijk, Ala Yaromina, Ruud Houben, Raymon Niemans, Philippe Lambin, Ludwig J. Dubois
Frontiers in Oncology.2016;[Epub] CrossRef
Review of Research Topics on Abdominal Examination
Jihye Kim, Jeong Hwan Park, Keun Ho Kim
Journal of Korean Medicine.2016; 37(3): 1. CrossRef
Expression of hypoxic markers and their prognostic significance in soft tissue sarcoma
JEUNG IL KIM, KYUNG UN CHOI, IN SOOK LEE, YOUNG JIN CHOI, WON TACK KIM, DONG HOON SHIN, KYUNGBIN KIM, JEONG HEE LEE, JEE YEON KIM, MEE YOUNG SOL
Oncology Letters.2015; 9(4): 1699. CrossRef
Evaluation of a Hypoxia Regulated Gene Panel in Ovarian Cancer
Amanda F. Baker, Scott W. Malm, Ritu Pandey, Cindy Laughren, Haiyan Cui, Denise Roe, Setsuko K. Chambers
Cancer Microenvironment.2015; 8(1): 45. CrossRef
Sulforaphane reduces molecular response to hypoxia in ovarian tumor cells independently of their resistance to chemotherapy
MICHAL PASTOREK, VERONIKA SIMKO, MARTINA TAKACOVA, MONIKA BARATHOVA, MARIA BARTOSOVA, LUBA HUNAKOVA, OLGA SEDLAKOVA, SONA HUDECOVA, OLGA KRIZANOVA, FRANCK DEQUIEDT, SILVIA PASTOREKOVA, JAN SEDLAK
International Journal of Oncology.2015; 47(1): 51. CrossRef
Overexpression of Glucose Transporter-1 (GLUT-1) Predicts Poor Prognosis in Epithelial Ovarian Cancer
Hanbyoul Cho, You Sun Lee, Julie Kim, Joon-Yong Chung, Jae-Hoon Kim
Cancer Investigation.2013; 31(9): 607. CrossRef
Towards Lipidomics of Low-Abundant Species for Exploring Tumor Heterogeneity Guided by High-Resolution Mass Spectrometry Imaging
Jonathan Cimino, David Calligaris, Johann Far, Delphine Debois, Silvia Blacher, Nor Sounni, Agnès Noel, Edwin De Pauw
International Journal of Molecular Sciences.2013; 14(12): 24560. CrossRef

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